Researchers at the University of Nottingham have developed a biocompatible, fluoride-free gel that triggers enamel regeneration using natural minerals found in saliva and reduces tooth sensitivity, infohub.kz reports.
Specialists from the University of Nottingham's School of Pharmacy and Department of Chemical and Environmental Engineering have made a breakthrough in dentistry by creating an innovative gel for regenerating tooth enamel. The findings were published in the journal Nature Communications. The development aims to overcome the main limitation of dental practice: mature teeth contain no living cells, which means enamel cannot repair itself after demineralization and erosion.
Unlike conventional varnishes and remineralizing pastes, the new formulation contains no fluoride. It is made up of biomimetic proteins that replicate the natural process of tooth formation in early childhood. When applied, the gel penetrates microcracks and forms a durable scaffold. On contact with saliva, the material attracts calcium and phosphate ions, triggering epitaxial mineralization — the ordered growth of crystals that bond seamlessly with the tooth's natural surface.
Tests confirmed that the grown layer matches the strength of healthy enamel and withstands brushing friction, chewing pressure and contact with acids. Lead author Abshar Hasan noted that the gel also proved highly effective when applied to exposed dentin, blocking channels to the nerves and eliminating hypersensitivity to hot and cold.
Study leader Alvaro Mata said the application procedure is as simple as standard fluoridation. To commercialize the technology, the authors have founded the company Mintech-Bio and plan to bring the first products to market within the next year.